GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs12748152 | 1 | rs12739698 | chr1:27230033 | GPATCH3 | chr1:27216980-27226962:- | 0.24 | 3.97 | 7.76E-5 | HDL cholesterol;Triglycerides;LDL cholesterol |
| BRCA | cis | rs12748152 | 1 | rs12741472 | chr1:27221609 | GPATCH3 | chr1:27216980-27226962:- | 0.23 | 4.12 | 4.02E-5 | HDL cholesterol;Triglycerides;LDL cholesterol |
| BRCA | cis | rs12748152 | 1 | rs12742376 | chr1:27285195 | GPATCH3 | chr1:27216980-27226962:- | 0.22 | 3.92 | 9.59E-5 | HDL cholesterol;Triglycerides;LDL cholesterol |
| BRCA | cis | rs12748152 | 1 | rs12752711 | chr1:27250258 | GPATCH3 | chr1:27216980-27226962:- | 0.22 | 3.99 | 6.94E-5 | HDL cholesterol;Triglycerides;LDL cholesterol |
| BRCA | cis | rs9253 | 1 | rs12754089 | chr1:37965304 | SNIP1 | chr1:38002145-38019903:- | -0.19 | -3.75 | 0.000184 | Hemostatic factors and hematological phenotypes |
| BRCA | cis | rs9253 | 1 | rs12754423 | chr1:37965549 | SNIP1 | chr1:38002145-38019903:- | -0.19 | -3.75 | 0.000184 | Hemostatic factors and hematological phenotypes |
| BRCA | cis | rs1275468 | 1 | rs1275468 | chr12:75935157 | GLIPR1L2 | chr12:75784889-75825591:+ | -0.24 | -7.35 | 4.04E-13 | Polycystic ovary syndrome |
| BRCA | cis | rs17401966 | 1 | rs12755094 | chr1:10305711 | PGD | chr1:10459085-10480200:+ | 0.18 | 5.24 | 1.98E-7 | Hepatocellular carcinoma |
| BRCA | cis | rs11590090 | 1 | rs12758837 | chr1:113311633 | FAM19A3 | chr1:113263189-113269854:+ | 0.21 | 6.28 | 5.04E-10 | Hyperactive-impulsive symptoms |
| BRCA | cis | rs11590090 | 1 | rs12758837 | chr1:113311633 | LRIG2 | chr1:113615831-113667342:+ | -0.11 | -3.38 | 0.000748 | Hyperactive-impulsive symptoms |
| BRCA | cis | rs9253 | 1 | rs12759356 | chr1:37957194 | SNIP1 | chr1:38002145-38019903:- | -0.2 | -3.83 | 0.000138 | Hemostatic factors and hematological phenotypes |
| BRCA | cis | rs12748152 | 1 | rs12760759 | chr1:27158344 | PIGV | chr1:27114455-27124886:+ | 0.22 | 3.74 | 0.000192 | HDL cholesterol;Triglycerides;LDL cholesterol |
| BRCA | cis | rs6583954 | 1 | rs12763230 | chr10:96629341 | HELLS | chr10:96305543-96361855:+ | 0.12 | 3.39 | 0.000719 | Migraine |
| BRCA | cis | rs17112901 | 1 | rs12767633 | chr10:102056440 | PKD2L1 | chr10:102047903-102090243:- | -0.23 | -4.25 | 2.28E-5 | Obesity-related traits |
| BRCA | cis | rs6583954 | 1 | rs12774450 | chr10:96401654 | HELLS | chr10:96305543-96361855:+ | 0.13 | 3.78 | 0.000168 | Migraine |